The primary focus of our lab is the study of T cell and Dendritic Cell subsets, and their roles in donor-specific transplantation tolerance and anti-tumor immunity. Active projects are evaluating how select T-cell and dendritic cell subsets can promote the engraftment of hematopoietic stem cells across wide MHC disparities, providing critical information for the use of stem cell therapy in a variety of settings, including transplantation and tissue regeneration. We are also studying how T cell and Dendritic cell subsets are modulated in the setting of lung cancer, with the specific aims of understanding how immune status influences outcomes in lung cancer, and how immunomodulation can be achieved to augment host responses to tumor.