Esophageal Cancer Risk Registry

Full Title

Esophageal Cancer Risk Registry

Purpose of Study

The purpose of this study is to identify markers in the blood and tissue that could indicate risk factors for the development and progression of esophagus cancer. This research aims to collect medical history, blood, and tissue samples from patients who present with an esophageal disorder. Identifying genetic and behavioral risk factors involved in the development of esophageal cancer might allow for early detection and prevention. Survival and an opportunity for a cure with esophageal cancer will depend greatly on the stage of diagnosis. Tumors can develop changes in their genetic (hereditary) make-up, and these changes can sometimes be seen in normal tissues before the development of cancer. These genetic (hereditary) changes can serve as tumor markers and can be detected using methods that study changes in genetic material like DNA and RNA. The analysis of proteins can provide additional information. By identifying changes in these molecules that are different or altered in cancer, the investigators can use methods and tests for the detection of these changes.

Sponsor: National Institutes of Health

Principal Investigator: James D. Luketich, MD


Research Type

Contact Information

James Luketich, MD 

Julie Ward, RN,BSN


  • Scheduled for a surgical intervention for the management of known or suspected esophageal or gastroesophageal junction malignancy, Barrett’s metaplasia, gastroesophageal reflux disease (GERD), achalasia, or hiatal hernia at the University of Pittsburgh Medical Center by one of the study investigators.
  • Agree to collection of blood and tissue samples at the time of surgery

For more information, visit link.